Great question — answering as the UphillTech team:
The systemtap stuff is supposed to let you drill down into the kernel, and lately also applications, for tracing, troubleshooting, and debugging. Haven't used it myself. High interrupt traffic for high network traffic might be due to less-than-bright network card or driver, perhaps a higer-end card gives better results. The kernel's handling of networking has also improved, perhaps updating the kernel helps. OTOH, if 50% of CPU usage goes to interrupts, and CPU utilization is 3%, there should be nothing to worry about... review the data you have (and how you collected it, what the exact meaning of the numbers is) and think it over. In the end, the question shouldn't be "Measuring foo gives...
Full answer by vonbrand: https://unix.stackexchange.com/a/70771 (CC BY-SA 3.0).
Need it done for your business? UphillTech.