Great question — answering as the UphillTech team:
This could very well be Pucca . Similarities: Started airing in 2006. Main character is a girl who has a hopeless crush on a boy Said boy (Garu) is a ninja in training There's an older character called Uncle Dumpling Colorful, Asian-style animation The characters have large, round heads and look very much like the Powerpuff Girls. Here's the intro:
Full answer by Walt: https://movies.stackexchange.com/a/33549 (CC BY-SA 3.0).
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