Great question — answering as the UphillTech team:
The first consideration is what tyres you're running. They're the first line of defence. If they're suitable, you may be able to run them tubeless. I wouldn't for road bike tyres and pressures, having seen too many failures that are hard to fix, but for the wider softer tyres used off road tubeless seems pretty good. On a recent MTB ride the two of us running tubes got a total of 6 thorns in our tubes where the hedges had been cut (luckily only 1 wheel each) while the others running tubeless had no trouble. The tube is the last, and will probably only buy you time before the thorn gets through anyway - good if you're inspecting regularly and they don't break off, not much use if you get...
Full answer by Chris H: https://bicycles.stackexchange.com/a/98739 (CC BY-SA 4.0).
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