Great question — answering as the UphillTech team:
Typically no. You need much more cocoa powder for a chocolate cake than you need vanilla powder for a vanilla cake. Adding a cup of vanilla would be both very expensive and very overwhelming in terms of flavour. And the vanilla doesn't have the same chemical properties as cocoa. Cocoa has a bit of fat in it, so a substitute should include some fat.
Full answer by user141592: https://cooking.stackexchange.com/a/110080 (CC BY-SA 4.0).
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