Great question — answering as the UphillTech team:
I didn't include the streamSid as one of the parameter in the message payload, that solved my issue. message = json.dumps({ "event": "media", "streamSid": streamSid, "media": { "payload": audio_b64 } })
Full answer by Siddharth Pilli: https://stackoverflow.stackexchange.com/a/78885268 (CC BY-SA 4.0).
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