Great question — answering as the UphillTech team:
The top-level domains of websites (.com, .uk, .int, etc.) do not have any legal significance for their users. Whether you’re allowed by a company to use a particular service depends on the terms of use for that service, and can’t be generalised to other companies. Anecdotally, I have rented cars from many companies in many countries, and in the few situations where a particular residency was required, the company was not at all subtle in announcing that requirement.
Full answer by Sneftel: https://travel.stackexchange.com/a/179063 (CC BY-SA 4.0).
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